Freespira Research in Clinical Settings

Posted On August 7, 2019

Today, I’m going to talk about the different types clinical trials we used when setting out to study the effectiveness of Freespira for people suffering from panic.

To make sure Freespira actually helps patients outside of a controlled test, we followed up on the randomized trial I discussed in my last blog with a real-world trial in clinics – meaning participants were just regular people seeking relief from their panic. Maybe just like you.  In real-world trials, patients are treated in regular clinical settings, but their results aren’t compared to a control group. It’s a different kind of trial to validate that individuals seeking treatment for their panic have the same results as those in a formal research environment.

This trial was conducted by Dr. David Tolin in association with Yale University.   Freespira treatment was offered to patients at five different locations across the country. These patients came from all walks of life, and many of them had been experiencing panic for over a decade. They used the same Freespira protocol as I described in our last blog – 28 days at home with weekly check-in visits at the clinic.

The great news is that results from Dr. Tolin’s ‘real-world’ study were very similar to the results from the earlier clinical trial:  85% of participants completing the Freespira treatment had clinically significant improvement at the end of the 28-days, and 82% were improved one year after treatment ended. And 70% of participants were in remission (no longer meeting criteria for a panic diagnosis) a full year post-treatment.

This study also highlighted benefits beyond reducing panic attacks, as participants reported reduced symptoms for measures associated with depression, agoraphobia, impairment of life function, and anxiety.

So what do we make of these two studies? The first take-away is that these studies prove Freespira is effective. The second is that the benefits are real – not just a placebo effect. And the third is that Freespira can help reduce symptoms of other conditions beyond panic to help people live their best lives.


  1. Tolin D, McGrath P, et al, A Multisite Benchmarking Trial of Capnometry Guided Respiratory Intervention for Panic Disorder in Naturalistic Treatment Settings, Journal of Applied Psychophysiology and Biofeedback, 42(1) 2017.


From time to time, Palo Alto Health Sciences (Freespira) will share articles or blog posts from guest authors. Some of the information presented may not be consistent with the science-based and clinically-proven method behind Freespira. In such cases, we share the article or blog post for general informational purposes only, without any endorsement or recommendation.